by the University of Michigan
ANN ARBOR, Mich.- Diesel engines emit countless carbon nanoparticles into the air, slipping through government regulation and vehicle fi lters. A new University of Michigan simulation shows that these nanoparticles can get trapped in the lungs and inhibit the function work of a fluid that facilitates breathing.
Lung surfactant is a naturally occurring fluid containing liquid made of proteins and lipids molecules. Itthat reduces surface tension in the lungs, prevents them from collapsing and helps transport foreign particles that will ultimately o fluids to be expelled from the lungs.in a sneeze. Inhaled cCarbon nanoparticles, however, appear to behave differently than most foreign particles. didn’t make it to the fluid in the U-M simulations. Computer simulations indicted that they would notn’t be expelled from the lungs, but would Instead, they becoame trapped in the surfactant, after becoming entangled with when fatty lipid molecules that wrapped their tails around the nanoparticles and into their central cavities.
“The presence of the nanoparticle can hinder the function of lung surfactant by affecting the interaction between the lipids and the peptides,” said Angela Violi, assistant professor in the College of Engineering.
Violi will present her findings during her invited talk at the American Chemical Society meeting on Aug. 20. A peptide is a piece of a protein.
This is the first time researchers have demonstrated how these nanoparticles can get caught in the lungs and affect the behavior of surfactant. Other studies have shown that buildup of nanoparticles in the lungs can lead to inflammation, blood clotting and changes in breathing and heart rates.
“There is mounting evidence that very small particles have a larger negative impact on health than larger particles,” Violi said. “Nanoparticles emitted by diesel engines and other combustion sources are a health concern because of both their size and the carcinogens with which they are associated. This problem is exacerbated by the fact that there is currently no effective regulatory control of these nanoparticles.”
Current U.S. and European diesel emissions regulations address particle sizes of . They apply to particles 2.5 microns or larger. (A micron is one-thousandth of a millimeter.) That’s still up to three orders of magnitude larger than these nanoparticles Dr. Violi studies. Carbon nanoparticles make up only 0.1 to 1.5 percent of the total mass of particles diesel engines emitspew, but when you look at the number of particles, the nanos compose between 35 percent and 97 percent of the emissions, depending on the traffic.
“With filters in cars, you can stop the soot, but you can’t stop these carbon nanoparticle cores, which are the most dangerous to humans,” Violi said. “Humans can stop larger soot particles in the nose or the throat.”
The computer model Violi created to run this simulation can also predict how various combustible materials will burn, what nanoparticles will be created, how those particles will be shaped and how they could affect the lungs. This tool could be useful in predicting figuring out biofuels emissions, Violi says.
“It could help us reach the goal of engineering biofuel molecules to reduce emissions,” Violi said. It’s conceivable that engineers could genetically modify a plants to produce cleaner burning fuelsburn cleaner, she said. Violi will also discuss these applications in her American Chemical Society talk.
Violi is an assistant professor in the departments of Mechanical Engineering, Chemical Engineering and Biomedical Engineering.
The presentation is called “Lipid membrane uptake of carbonaceous nanoparticles from combustion sources.” It is at 1:30 p.m. on August 20, 2008 at the American Chemical Society fall meeting in Philadelphia. A related paper on this research titled “Molecular Dynamics Simulation Study of a Pulmonary Surfactant Film Interacting with a Carbonaceous Nanoparticle” will be published in the Oct. 15 issue of Biophysical Journal.
